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. Block diagram of the HPLC–MS. A three element combination enters the HPLC. When part A elutes through the column, it enters the MS ion resource and ionizes to form the mum or dad ion and several other fragment ions.The column measurement is identical. The column is stuffed with silica particles that happen to be modified to make them non-polar.
Drug antagonism happens when one drug's exercise is countered by A further drug's action on exactly the same pharmacological system.For example, being a substrate of each CYP3A and P-gp, tacrolimus concentrations will improve or decrease with concomitant administration of drugs that inhibit or induce these pathways, respectively (Staatz and Tett, 2
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